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Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.

“What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for,” said Ryan Tewhey, Ph.D., an associate professor at The Jackson Laboratory and co-senior author of the work. “This creates the opportunity for us to turn the expression of a gene up or down in just one tissue without affecting the rest of the body.”

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Anu Bradford wins the 2024 Stein Rokkan Prize with her ‘path-breaking’ book

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https://council.science/news/anu-bradford-wins-2024-stein-rokkan-prize/

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ISC Governing Board elections 2024 – designate your voting delegate by 1 December

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https://council.science/news/isc-gb-elections-2024/?utm_source=rss&utm_medium=rss&utm_campaign=isc-gb-elections-2024

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submitted 2 weeks ago* (last edited 2 weeks ago) by [email protected] to c/[email protected]
 
 

A new vaccine provides hope for treating and even preventing the highly contagious and difficult-to-treat Clostridioides difficile infection, more commonly known as C. difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers at the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia. The results, published in the journal Science, will pave the way for clinical trials of the vaccine.

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