this post was submitted on 25 Feb 2024
507 points (90.6% liked)

Cool Guides

4701 readers
2 users here now

Rules for Posting Guides on Our Community

1. Defining a Guide Guides are comprehensive reference materials, how-tos, or comparison tables. A guide must be well-organized both in content and layout. Information should be easily accessible without unnecessary navigation. Guides can include flowcharts, step-by-step instructions, or visual references that compare different elements side by side.

2. Infographic Guidelines Infographics are permitted if they are educational and informative. They should aim to convey complex information visually and clearly. However, infographics that primarily serve as visual essays without structured guidance will be subject to removal.

3. Grey Area Moderators may use discretion when deciding to remove posts. If in doubt, message us or use downvotes for content you find inappropriate.

4. Source Attribution If you know the original source of a guide, share it in the comments to credit the creators.

5. Diverse Content To keep our community engaging, avoid saturating the feed with similar topics. Excessive posts on a single topic may be moderated to maintain diversity.

6. Verify in Comments Always check the comments for additional insights or corrections. Moderators rely on community expertise for accuracy.

Community Guidelines

By following these rules, we can maintain a diverse and informative community. If you have any questions or concerns, feel free to reach out to the moderators. Thank you for contributing responsibly!

founded 1 year ago
MODERATORS
 
you are viewing a single comment's thread
view the rest of the comments
[–] [email protected] 26 points 9 months ago (3 children)

Let's not forget this only refers to LD50 not permanent organ damage.

[–] [email protected] 15 points 9 months ago* (last edited 9 months ago)

Exactly. Gasoline, for example, is remarkably non-toxic, but it will cause instant chemical burns to your throat and lungs, possibly killing you far below the (chemically) lethal dose.

Methanol will turn you blind at a quarter of the listed dose, and those two are just from the top of my head.

[–] [email protected] 1 points 9 months ago (2 children)

I wonder how they came up with the LD50 of all those materials, like THC and LSD. Is this based on theoretical calculation, in vitro tests, or on a (assumably) very small sample of known deaths?

[–] [email protected] 7 points 9 months ago* (last edited 9 months ago) (1 children)

Step 1: Feed/Inject mutliple rat populations with different concentrations
Step 2: See how many die.
Step 3: The concentration which causes 50% of the population to die is the LD50

[–] [email protected] 2 points 9 months ago

While I was thinking you were yet another user, you were a rat the whole time! Wait, we are all rats!

Jokes aside, animal testing as a data source seems reasonable to me. Thanks

[–] [email protected] 2 points 9 months ago

All the above, most likely

[–] [email protected] 1 points 9 months ago* (last edited 9 months ago)

Or aspects like arsenic staying in your body a very long time, or the fact that LSD is psychoactive in microgram doses, so you'd need thousands of tabs to die.